Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 132
interventional 98
Observational 28
Registry 6

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 39
Device 16
Biological|Drug 6
Radiation 6
Drug|placebo 3
Other 3
Procedure 3
Device|Drug 2
Device|Procedure 2
Drug|Other 2
Drug|Radiation 2
Procedure|Radiation 2
Behavioral|Device 1
Behavioral|Other|Procedure 1
Behavioral|Radiation 1
Biological 1
Biological|Dietary Supplement 1
Biological|Drug|Other 1
Biological|Drug|Procedure|Radiation 1
Combination Product 1
Device|Radiation 1
Drug|Genetic 1
Drug|Procedure 1
Other|Procedure|Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 27
NA 11
France 9
China 6
Canada 3
Israel 3
Italy 3
Netherlands 3
Australia 2
Brazil 2
Bulgaria 2
Egypt 2
Germany 2
United Kingdom 2
United States|France 2
Algeria|Brazil|Egypt|India|Lithuania|Macedonia, The Former Yugoslav Republic of|Mexico|Serbia|Spain|Tunisia|United Kingdom 1
Argentina|Austria|Belgium|Brazil|Czechia|France|Hungary|Israel|Italy|Japan|Latvia|Lithuania|Panama|Peru|Poland|Russian Federation|South Africa|Spain|Ukraine 1
Belgium|France|Netherlands|Switzerland 1
Brazil|Canada|Italy 1
Czech Republic|United Kingdom 1
Finland 1
Finland|Germany|Italy|Netherlands 1
France|Italy|Netherlands 1
Hungary 1
Korea, Republic of 1
Taiwan 1
Turkey 1
United States|Argentina|Australia|Austria|Brazil|Canada|Egypt|India|Netherlands|Singapore|South Africa|Spain 1
United States|Australia|Austria|Canada|France|Germany|Italy|Netherlands|Poland|Spain|Sweden|United Kingdom 1
United States|Australia|France|Italy|Poland|Spain|Sweden|United Kingdom 1
United States|Canada 1
United States|Canada|Denmark|Norway|Portugal|Spain|Sweden|United Kingdom 1
United States|Canada|Puerto Rico 1
United States|Netherlands 1

Sites per Study

Site_count Study_Count
1 56
2 7
3 4
4 1
5 1
6 5
7 2
8 2
9 2
10 1
11 1
12 1
13 1
14 1
15 1
17 2
20 1
22 1
28 1
30 1
31 1
33 2
54 1
64 1
317 1

Phase

Phase Study_Count
N/A 23
Phase 2 19
Phase 3 19
Phase 1 12
Phase 4 12
Phase 1/Phase 2 8
Early Phase 1 3
Phase 2/Phase 3 2

Number of Arms

Number_of_Arms Count_of_Studies
1 50
2 32
3 6
4 2
5 1
8 1
NA 6

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 20.00000 10.00000 3.00 2.0 13.0000 60 35.0000 44.00
1st Qu. 25.00000 29.50000 10.00 23.5 38.5000 120 124.5000 66.75
Median 30.00000 60.00000 23.50 36.0 60.0000 180 240.0000 152.00
Mean 33.33333 86.43478 24.50 106.5 105.6316 180 514.5263 184.25
3rd Qu. 40.00000 86.00000 41.25 132.5 105.5000 240 506.5000 288.00
Max. 50.00000 455.00000 50.00 350.0 535.0000 300 2049.0000 432.00

Trial Group Type

group_type Group_Count
Experimental 109
Active Comparator 28
No Intervention 7
Other 6
NA 6
Placebo Comparator 3

Intervention Model

intervention_model Study_Count
Single Group Assignment 52
Parallel Assignment 42
NA 2
Crossover Assignment 1
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 68
Supportive Care 14
Diagnostic 6
Prevention 6
Other 2
Screening 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 7
Italy 4
Canada 2
Egypt 2
France 2
Belgium|France 1
China 1
Czech Republic 1
Denmark 1
Finland 1
Germany 1
Ireland 1
Korea, Republic of 1
NA 1
Norway 1
Panama 1

Sites per Study

Site_count Study_Count
1 21
2 3
3 3
8 1

Enrollment Metrics

Measure Observational
Min 8.0000
1st Qu 45.0000
Median 86.5000
Mean 272.8571
3rd Qu 207.5000
Max 2500.0000

Observation Model

observational_model Study_Count
Cohort 19
Case-Only 7
Case-Control 2

Time Perspective

time_perspective Study_Count
Prospective 17
Retrospective 6
Cross-Sectional 5

Registries

Studies by Country

Country Study_Count
Italy 2
Netherlands 2
United States 2

Sites per Study

Site_count Study_Count
1 6

Enrollment Metrics

Measure Registries
Min 120.000
1st Qu 312.250
Median 800.000
Mean 1067.167
3rd Qu 1725.000
Max 2500.000

Registry Model

observational_model Study_Count
Cohort 5
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 5
Other 1

Follow-up

target_duration Study_Count
12 Months 2
2 Years 1
3 Years 1
30 Years 1
5 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03449108 LN-145 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas https://ClinicalTrials.gov/show/NCT03449108 Recruiting M.D. Anderson Cancer Center 2020-12-31
NCT03301857 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 https://ClinicalTrials.gov/show/NCT03301857 Active, not recruiting Amgen 2023-07-25
NCT03295981 Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone https://ClinicalTrials.gov/show/NCT03295981 Recruiting St. Louis University 2022-01-31
NCT03093909 Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases https://ClinicalTrials.gov/show/NCT03093909 Recruiting M.D. Anderson Cancer Center 2021-11-30
NCT02901782 The Application of Personalized Titanium Plate in the Bone Tumors Around the Knee https://ClinicalTrials.gov/show/NCT02901782 Completed Guangzhou General Hospital of Guangzhou Military Command 2016-08-31
NCT02893397 Supervised Exercise in Improving Physical Fitness Before Surgery in Patients With Resectable Bone Cancer https://ClinicalTrials.gov/show/NCT02893397 Recruiting M.D. Anderson Cancer Center 2020-08-30
NCT02880943 Dose-finding, Safety and Efficacy Study of Radium-223 Dichloride (XOFIGO) in RCC Patients With Bone Metastases. (EIFFEL) https://ClinicalTrials.gov/show/NCT02880943 Active, not recruiting Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie 2020-10-31
NCT02876731 Comparison of NaF PET-CT and Diffusion MRI in the Diagnosis of Bone Metastases (IMMETAOS) https://ClinicalTrials.gov/show/NCT02876731 Completed Institut Jean-Godinot 2015-06-30
NCT02862288 Preliminary Study of Microwave Tumoral Ablation Performances for the Treatment of Pulmonary, Renal and Bone Neoplasia. https://ClinicalTrials.gov/show/NCT02862288 Completed Centre Hospitalier Universitaire de Besancon 2015-02-28
NCT02839291 Evaluation of Medical Practice in the Management of Bone Metastases After Injectable Bone Antiresorptive Treatment, and Its Influence on Quality of Life https://ClinicalTrials.gov/show/NCT02839291 Recruiting Centre Hospitalier Universitaire de Besancon 2019-11-30
NCT02784652 Efficacy of Radiotherapy in Combination With Zoledronic Acid in Bone Metastasis Patients With Gastrointestinal Tumors https://ClinicalTrials.gov/show/NCT02784652 Completed Severance Hospital 2017-02-28
NCT02716792 A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer https://ClinicalTrials.gov/show/NCT02716792 Completed Hoffmann-La Roche 2008-06-30
NCT02618369 MR-Guided High Intensity Focused Ultrasound for Pain Management Of Osteoid Osteoma & Benign Bone Tumors in Children and Adults https://ClinicalTrials.gov/show/NCT02618369 Completed The Hospital for Sick Children 2018-04-30
NCT03204942 Dorsal Root Ganglion Thermal Radiofrequency Versus Pulsed Radiofrequency for Metastatic Pain in Thoracic Vertebral Body https://ClinicalTrials.gov/show/NCT03204942 Completed National Cancer Institute, Egypt 2018-07-30
NCT03404362 MRgFUS Versus EBRT in Patients With Metastatic Non-spinal Bone Disease https://ClinicalTrials.gov/show/NCT03404362 Completed University of Roma La Sapienza 2016-12-31
NCT02564107 A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease https://ClinicalTrials.gov/show/NCT02564107 Completed Hoffmann-La Roche 2006-04-30
NCT02561039 A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease https://ClinicalTrials.gov/show/NCT02561039 Completed Hoffmann-La Roche 2008-03-31
NCT02553707 A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer https://ClinicalTrials.gov/show/NCT02553707 Completed Hoffmann-La Roche 2008-12-31
NCT03389724 Prevention of Chemotherapy Induced Cardiotoxicity in Children With Bone Tumors and Acute Myeloid Leukemia https://ClinicalTrials.gov/show/NCT03389724 Recruiting Children’s Cancer Hospital Egypt 57357 2020-11-14
NCT02544711 Cost-effectiveness Evaluation of the Use of a Patient Specific Instrument for Surgical Resection of Malignant Bone Tumor Within the Pelvis Versus the Conventional Surgical Treatment https://ClinicalTrials.gov/show/NCT02544711 Recruiting Nantes University Hospital 2021-04-30
NCT02511678 Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases https://ClinicalTrials.gov/show/NCT02511678 Completed Galil Medical, a wholly owned indirect subsidiary of Boston Scientific 2018-03-12
NCT02464696 Early Non Invasive Ventilation and Hematological Malignancies https://ClinicalTrials.gov/show/NCT02464696 Recruiting M.D. Anderson Cancer Center 2020-10-01
NCT02426697 Pain Management With Pecfent in the Prevention of Pain Induced by Position in Radiotherapy https://ClinicalTrials.gov/show/NCT02426697 Recruiting Centre Henri Becquerel 2018-12-31
NCT02398058 Trabectedin Plus Olaparib in Metastatic or Advanced Sarcomas (TOMAS) https://ClinicalTrials.gov/show/NCT02398058 Recruiting Italian Sarcoma Group 2020-02-29
NCT02376322 Hypofractionated Radiotherapy (16/2) for the Palliation of Complicated Bone Metastases in Patients With KPS https://ClinicalTrials.gov/show/NCT02376322 Completed Santa Casa de Porto Alegre 2016-07-30
NCT02364115 Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study https://ClinicalTrials.gov/show/NCT02364115 Completed UMC Utrecht 2019-05-31
NCT02323295 Effect of High Doses of Radiation on Bone Structure and Metabolism https://ClinicalTrials.gov/show/NCT02323295 Recruiting Massachusetts General Hospital 2019-07-31
NCT02306161 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma https://ClinicalTrials.gov/show/NCT02306161 Active, not recruiting National Cancer Institute (NCI) 2020-12-31
NCT02303366 Pilot Study of Stereotactic Ablation for Oligometastatic Breast Neoplasia in Combination With the Anti-PD-1 Antibody MK-3475 https://ClinicalTrials.gov/show/NCT02303366 Completed Peter MacCallum Cancer Centre, Australia 2017-04-30
NCT02274623 Effect of CTAP101 Capsules on Ca/iPTH in Advanced Breast/Prostate Cancer Patients Treated With Denosumab/Zoledronic Acid https://ClinicalTrials.gov/show/NCT02274623 Completed OPKO Health, Inc. 2017-02-27
NCT02192333 Survivorship Care in Reducing Symptoms in Young Adult Cancer Survivors https://ClinicalTrials.gov/show/NCT02192333 Active, not recruiting Fred Hutchinson Cancer Research Center 2017-10-07
NCT02163226 A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of Symptoms https://ClinicalTrials.gov/show/NCT02163226 Active, not recruiting M.D. Anderson Cancer Center 2021-06-30
NCT02103634 NaF PET/MRI Evaluation for Bone Metastases in Breast Cancer https://ClinicalTrials.gov/show/NCT02103634 Completed Case Comprehensive Cancer Center 2018-12-21
NCT02085941 Image-guided Cryoablation of Head, Neck and Spine Tumors https://ClinicalTrials.gov/show/NCT02085941 Recruiting Dana-Farber Cancer Institute 2020-06-30
NCT01304121 Bioactive Glass Granules in Filling of Bone Defects https://ClinicalTrials.gov/show/NCT01304121 Completed Turku University Hospital 2010-12-31
NCT01833806 A Phase IV Post Approval Clinical Study of ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain https://ClinicalTrials.gov/show/NCT01833806 Recruiting InSightec 2020-06-30
NCT01784393 Chemoradiation for Bone Metastasis https://ClinicalTrials.gov/show/NCT01784393 Completed Rabin Medical Center 2007-04-30
NCT01765907 Antalgic Treatment of Painful Bone Metastases by US-guided High Intensity Focused Ultrasound (HIFU) https://ClinicalTrials.gov/show/NCT01765907 Completed Theraclion 2014-03-31
NCT01669499 Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009 https://ClinicalTrials.gov/show/NCT01669499 Completed UMC Utrecht 2016-04-30
NCT01553539 Therapeutic Angiotensin-(1-7) in Treating Patients With Metastatic Sarcoma That Cannot Be Removed By Surgery https://ClinicalTrials.gov/show/NCT01553539 Completed Wake Forest University Health Sciences 2013-01-31
NCT01479283 Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) https://ClinicalTrials.gov/show/NCT01479283 Active, not recruiting McMaster University 2020-12-31
NCT01419717 Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer https://ClinicalTrials.gov/show/NCT01419717 Completed Amgen 2018-08-10
NCT01409720 Isometric Muscle Training in Patients With Spinal Bony Metastases Under Radiation Therapy https://ClinicalTrials.gov/show/NCT01409720 Completed Heidelberg University 2012-09-30
NCT01336803 Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI https://ClinicalTrials.gov/show/NCT01336803 Completed Stanford University 2014-07-31
NCT04310410 Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis https://ClinicalTrials.gov/show/NCT04310410 Recruiting UMC Utrecht 2020-04-01
NCT04307914 Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients With Bone Metastases https://ClinicalTrials.gov/show/NCT04307914 Recruiting UMC Utrecht 2024-01-01
NCT04178044 Phase â…  Clinical Study Protocol of GB223 Monoclonal Antibody Injection https://ClinicalTrials.gov/show/NCT04178044 Recruiting Genor Biopharma Co., Ltd. 2020-12-31
NCT03986593 Cryoablation of Bone Metastases From Endocrine Tumors https://ClinicalTrials.gov/show/NCT03986593 Recruiting Instituto do Cancer do Estado de São Paulo 2021-06-15
NCT03905174 Massive Implants the Next Generation https://ClinicalTrials.gov/show/NCT03905174 Recruiting Royal National Orthopaedic Hospital NHS Trust 2021-10-31
NCT03678883 9-ING-41 in Patients With Advanced Cancers https://ClinicalTrials.gov/show/NCT03678883 Recruiting Actuate Therapeutics Inc. 2022-11-30
NCT03669523 Denosumab and Nivolumab Combination as 2d-line Therapy in Stage IV NSC Lung Cancer With Bone Metastases (DENIVOS) https://ClinicalTrials.gov/show/NCT03669523 Recruiting Centre Hospitalier Annecy Genevois 2022-09-30
NCT03661892 Pilot, Syndros, Decreasing Use of Opioids in Breast Cancer Subjects With Bone Mets https://ClinicalTrials.gov/show/NCT03661892 Recruiting University of Arizona 2020-12-30
NCT03605199 Denosumab in Subjects With Giant Cell Rich Tumors of Bone https://ClinicalTrials.gov/show/NCT03605199 Recruiting Leiden University Medical Center 2021-06-30
NCT03547557 MR Guided Focused Ultrasound Surgery in the Treatment of Pain From Bone Tumors w/ the ExAblate 2000 Strappable System https://ClinicalTrials.gov/show/NCT03547557 Completed InSightec 2009-02-28
NCT03527888 Study of Anlotinib in Patients With Primary Malignant Bone Tumors https://ClinicalTrials.gov/show/NCT03527888 Active, not recruiting Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 2019-12-31
NCT03525392 Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1. https://ClinicalTrials.gov/show/NCT03525392 Recruiting Ipsen 2021-04-20
NCT03503682 Short Course Radiation Therapy in Palliative Treatment of Complicated Bone Metastases https://ClinicalTrials.gov/show/NCT03503682 Recruiting Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi 2022-11-08
NCT03495921 Vigil + Irinotecan and Temozolomide in Ewing’s Sarcoma https://ClinicalTrials.gov/show/NCT03495921 Active, not recruiting Gradalis, Inc. 2021-12-31
NCT03479151 Magnetic Resonance Guided High Intensity Focused Ultrasound (MRgHIFU) for Pain Palliation of Bone Metastases https://ClinicalTrials.gov/show/NCT03479151 Recruiting Institute of Cancer Research, United Kingdom 2020-09-30
NCT03420963 Ex-Vivo Expanded Allogeneic NK Cells For The Treatment Of Pediatric Solid Tumors https://ClinicalTrials.gov/show/NCT03420963 Recruiting M.D. Anderson Cancer Center 2022-12-01
NCT01248585 Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases https://ClinicalTrials.gov/show/NCT01248585 Completed Canadian Cancer Trials Group 2015-02-28
NCT01129336 Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients https://ClinicalTrials.gov/show/NCT01129336 Completed Novartis 2012-08-31
NCT01117246 Pilot Study for Palliation of Pain in Bone Metastases by MR-HIFU https://ClinicalTrials.gov/show/NCT01117246 Completed Philips Healthcare 2011-07-31
NCT01091883 Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma https://ClinicalTrials.gov/show/NCT01091883 Completed InSightec 2019-01-31
NCT01085565 Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System https://ClinicalTrials.gov/show/NCT01085565 Completed InSightec 2013-03-31
NCT00956163 Whole Body Fluorine F 18 Sodium Fluoride PET/CT Scan and Whole Body MRI in Finding Bone Metastases in Patients With Prostate Cancer https://ClinicalTrials.gov/show/NCT00956163 Completed National Cancer Institute (NCI) 2011-01-31
NCT00950911 Open Label Extension to SRE Studies in United Kingdom and Czech Republic Only https://ClinicalTrials.gov/show/NCT00950911 Completed Amgen 2012-02-29
NCT00858741 Palliative Radiotherapy for Bone Metastases: Single Versus Multiple Fractions. https://ClinicalTrials.gov/show/NCT00858741 Completed Marilia Medicine School NA
NCT02880319 Evaluating Stereotactic Body Radiation Therapy for Oligometastatic Disease of the Bone https://ClinicalTrials.gov/show/NCT02880319 Recruiting Dana-Farber Cancer Institute 2021-05-31
NCT02826382 Preliminary Evaluation of Uptake in Bone Metastases and Biodistribution of [68Ga]P15-041 https://ClinicalTrials.gov/show/NCT02826382 Recruiting Five Eleven Pharma, Inc. 2020-11-20
NCT01106352 A Study of Alpharadin With Docetaxel in Patients With Bone Metastasis From Castration-Resistant Prostate Cancer (CRPC) https://ClinicalTrials.gov/show/NCT01106352 Completed Bayer 2015-06-30
NCT00765687 Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates https://ClinicalTrials.gov/show/NCT00765687 Completed Sun Yat-sen University 2012-05-31
NCT00762346 Efficacy and Safety Study of ZOMETA® in Treatment of High-level NTX Non Small Cell Lung Cancer With Bone Metastasis https://ClinicalTrials.gov/show/NCT00762346 Completed Sun Yat-sen University 2013-03-31
NCT00680992 Study of Denosumab in Subjects With Giant Cell Tumor of Bone https://ClinicalTrials.gov/show/NCT00680992 Completed Amgen 2018-05-17
NCT00667199 BAY88-8223, Does Response Study in HRPC Patients https://ClinicalTrials.gov/show/NCT00667199 Completed Bayer 2008-04-01
NCT00610272 Optimization of Radiotherapy in Treatment of Painful Bone Metastasis https://ClinicalTrials.gov/show/NCT00610272 Completed International Atomic Energy Agency 2012-04-30
NCT00598741 Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors https://ClinicalTrials.gov/show/NCT00598741 Completed Memorial Sloan Kettering Cancer Center 2014-04-30
NCT00566618 Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis https://ClinicalTrials.gov/show/NCT00566618 Active, not recruiting M.D. Anderson Cancer Center 2021-01-31
NCT00558272 Study to Evaluate the Safety and Effects AZD0530 on Prostate and Breast Cancer Subjects With Metastatic Bone Disease https://ClinicalTrials.gov/show/NCT00558272 Completed AstraZeneca 2010-01-31
NCT00524849 Zometa and Circulating Vascular Endothelial Growth Factor (VEGF) in Breast Cancer Patients With Bone Metastasis https://ClinicalTrials.gov/show/NCT00524849 Completed Fudan University 2008-08-31
NCT00502736 A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Malignant Bone Disease. https://ClinicalTrials.gov/show/NCT00502736 Completed Hoffmann-La Roche 2009-03-31
NCT00464620 Trial of Dasatinib in Advanced Sarcomas https://ClinicalTrials.gov/show/NCT00464620 Completed Sarcoma Alliance for Research through Collaboration 2016-12-31
NCT00020267 Vaccine Therapy in Treating Patients With Metastatic Cancer https://ClinicalTrials.gov/show/NCT00020267 Completed National Cancer Institute (NCI) NA
NCT00019630 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT00019630 Completed National Cancer Institute (NCI) NA
NCT00434447 Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases https://ClinicalTrials.gov/show/NCT00434447 Completed Novartis 2009-09-30
NCT00396279 Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone https://ClinicalTrials.gov/show/NCT00396279 Completed Amgen 2008-04-07
NCT00350233 MR Guided Focused Ultrasound Surgery of Metastatic Bone Tumors https://ClinicalTrials.gov/show/NCT00350233 Completed InSightec 2010-02-28
NCT00334139 Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer https://ClinicalTrials.gov/show/NCT00334139 Completed Novartis 2009-07-31
NCT00330759 Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma. https://ClinicalTrials.gov/show/NCT00330759 Completed Amgen 2009-04-01
NCT00321620 Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Men With Hormone-refractory Prostate Cancer https://ClinicalTrials.gov/show/NCT00321620 Completed Amgen 2009-10-01
NCT00321464 A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects. https://ClinicalTrials.gov/show/NCT00321464 Completed Amgen 2009-07-20
NCT00264420 Safety and Efficacy Study of Concomitant Radiotherapy and Zoledronic Acid for Bone Metastases Palliation https://ClinicalTrials.gov/show/NCT00264420 Completed The Cleveland Clinic NA
NCT00241111 Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis https://ClinicalTrials.gov/show/NCT00241111 Completed Novartis 2006-01-31
NCT00237159 Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis https://ClinicalTrials.gov/show/NCT00237159 Completed Novartis 2005-12-31
NCT00219258 Efficacy and Safety of Zoledronic Acid in Patients With Bone Metastases of Any Solid Tumors or Multiple Myeloma https://ClinicalTrials.gov/show/NCT00219258 Completed Novartis NA
NCT00211211 FREE Study - Fracture Reduction Evaluation https://ClinicalTrials.gov/show/NCT00211211 Completed Medtronic Spinal and Biologics 2007-12-31
NCT00168129 Helical Tomotherapy as a Radiotherapy Technique for Treating Bone Metastases https://ClinicalTrials.gov/show/NCT00168129 Completed AHS Cancer Control Alberta NA
NCT00104650 Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous (IV) Bisphosphonates https://ClinicalTrials.gov/show/NCT00104650 Completed Amgen 2008-01-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03129672 Distal Tibia Sarcoma Treatment Using Allograft Arthrodesis of the Ankle https://ClinicalTrials.gov/show/NCT03129672 Recruiting Hospital del Niño “Dr. José Renán Esquivel” 2019-06-01
NCT02996734 Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment https://ClinicalTrials.gov/show/NCT02996734 Completed Istituto Ortopedico Rizzoli 2016-12-31
NCT02810262 Association of Bone and Metabolic Parameters With Overall Survival in Patients With Bone Metastases From Adenocarcinoma Lung Cancer (POUMOS) https://ClinicalTrials.gov/show/NCT02810262 Recruiting Hospices Civils de Lyon 2019-12-31
NCT02774213 A Study to Collect Data About Analgesia in Patients With Bone Metastasis https://ClinicalTrials.gov/show/NCT02774213 Completed Tools4Patient 2017-04-28
NCT02557243 Malignant Pediatric Soft Tissue & Bone Tumors of the Extremities: A Retrospective Study https://ClinicalTrials.gov/show/NCT02557243 Completed Assiut University 2019-11-30
NCT02410044 Prospective PRO/QoL Registry for Patients With Bone Metastases of Breast or Prostate Cancer https://ClinicalTrials.gov/show/NCT02410044 Active, not recruiting iOMEDICO AG 2019-08-16
NCT02107664 The Palliative Radiotherapy And Inflammation Study - PRAIS https://ClinicalTrials.gov/show/NCT02107664 Completed Norwegian University of Science and Technology 2017-12-31
NCT01470105 Improving a Bayesian Model’s Survival Estimates in Patients Needing Surgery for Bone Metastases https://ClinicalTrials.gov/show/NCT01470105 Active, not recruiting Memorial Sloan Kettering Cancer Center 2021-11-30
NCT04167605 Evaluation of Prognostic Factors: From Breast Cancer to Bone Metastases https://ClinicalTrials.gov/show/NCT04167605 Recruiting Istituto Ortopedico Galeazzi 2022-11-12
NCT04074291 Cross Cultural Validation of the Italian Version of the Bt-DUX https://ClinicalTrials.gov/show/NCT04074291 Recruiting Istituto Ortopedico Rizzoli 2020-08-30
NCT03979118 Exercise Prescription in Patients With Bone Metastases https://ClinicalTrials.gov/show/NCT03979118 Recruiting University of Dublin, Trinity College 2021-01-31
NCT03963531 Patterns of Care and Outcomes in Patients With Metastatic Bone Tumors (METABONE) https://ClinicalTrials.gov/show/NCT03963531 Recruiting Institut Bergonié 2016-01-31
NCT03924609 Impact of Intensive Follow-up for Bone Metastasis on Characteristics and Prognosis of Chinese Breast Cancer Patients https://ClinicalTrials.gov/show/NCT03924609 Completed Peking University People’s Hospital 2019-03-31
NCT03908853 Pain Phenotyping of Patients With Bone Cancer Pain https://ClinicalTrials.gov/show/NCT03908853 Recruiting University of Copenhagen 2021-04-01
NCT03895216 Identification and Characterization of Predictive Factors of Onset of Bone Metastases in Cancer Patients https://ClinicalTrials.gov/show/NCT03895216 Recruiting Istituto Ortopedico Rizzoli 2020-06-30
NCT03839095 Localized Osteosarcoma in Upper Egypt: A Clinical Prediction Model https://ClinicalTrials.gov/show/NCT03839095 Completed Assiut University 2018-07-20
NCT03814811 Circulating Osteocalcin-positive Cells in Breast Cancer Bone Metastasis https://ClinicalTrials.gov/show/NCT03814811 Recruiting Seoul National University Hospital 2017-09-30
NCT03442465 Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas https://ClinicalTrials.gov/show/NCT03442465 Recruiting Memorial Sloan Kettering Cancer Center 2021-02-14
NCT01254929 F-18 PET Bone Scans Versus Tc-99m Bone Scans for the Diagnosis of Bone Metastases https://ClinicalTrials.gov/show/NCT01254929 Completed Seattle Nuclear Medicine 2014-02-28
NCT01144481 Risk Factors for Skeletal Related Events in Breast Cancer Patients Receiving Bisphosphonates for Bone Metastases https://ClinicalTrials.gov/show/NCT01144481 Completed University Health Network, Toronto 2013-04-30
NCT01135849 B-Receptor Signaling in Cardiomyopathy https://ClinicalTrials.gov/show/NCT01135849 Completed Stanford University 2010-10-31
NCT00935870 Bioactive Glass as Bone Graft Substitute in Operative Treatment of Bone - a 10 Years Follow-up Study https://ClinicalTrials.gov/show/NCT00935870 Completed Vivoxid Ltd 2008-06-30
NCT00909142 Bonefos and the Consumption of Analgesics https://ClinicalTrials.gov/show/NCT00909142 Completed Bayer 2009-02-28
NCT00824213 Pilot Project: Fast Whole-body Spect Scanning to Improve the Detection of Bone Metastases in Patients With Diagnosed Cancer https://ClinicalTrials.gov/show/NCT00824213 Completed University of British Columbia 2016-08-10
NCT04002817 Giant Cell Tumor of the Bone in Young Patients https://ClinicalTrials.gov/show/NCT04002817 Active, not recruiting Istituto Ortopedico Rizzoli 2019-12-30
NCT00594776 Vascular CT Assessment of Structural Autograft and Allograft Healing https://ClinicalTrials.gov/show/NCT00594776 Completed University of Rochester 2015-12-31
NCT00160758 Physical Characteristics of Retrieved Massive Allografts https://ClinicalTrials.gov/show/NCT00160758 Completed University of Florida 2009-09-30
NCT00160719 HLA Sensitization Following Major Cortical Allograft Bone Procedures https://ClinicalTrials.gov/show/NCT00160719 Completed University of Florida 2010-03-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03188926 Surgical Treatment of Long Bone Metastases https://ClinicalTrials.gov/show/NCT03188926 Recruiting Istituto Ortopedico Rizzoli 2017-12-31
NCT03160274 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions https://ClinicalTrials.gov/show/NCT03160274 Recruiting The University of Texas Health Science Center at San Antonio 2030-12-31
NCT02705157 The OPTIMAL Study - A Prospective Cohort of Patients With Bone Metastases of the Long Bones https://ClinicalTrials.gov/show/NCT02705157 Recruiting Leiden University Medical Center 2018-01-31
NCT02677961 An Electronic Health Record (EHR)-Based Comprehensive Bone and Soft Tissue Tumor Registry https://ClinicalTrials.gov/show/NCT02677961 Recruiting Ohio State University Comprehensive Cancer Center 2020-06-30
NCT02356497 Prospective Evaluation of Interventional Studies on Bone Metastases - the PRESENT Cohort https://ClinicalTrials.gov/show/NCT02356497 Recruiting UMC Utrecht 2022-12-31
NCT04104750 The Assessment of Fatigue and Quality of Life in Patients With Bone Tumor, https://ClinicalTrials.gov/show/NCT04104750 Recruiting Istituto Ortopedico Rizzoli 2022-08-20